Molecular diagnostic testing identifies pathogens at a greater rate than conventional microbiology. doi: 10.1001/ detection of coinfections is important to initiate appropriate antimicrobial therapy. The third international consensus definitions for sepsis and septic shock (Sepsis-3) JAMA. Singer M, Deutschman CS, Seymour CW, et al. Procalcitonin to reduce long-term infection-associated adverse events in sepsis: a randomized trial. Kyriazopoulou E, Liaskou-Antoniou L, Adamis G, et al. Community-acquired pneumonia requiring hospitalization among US adults. Comparative analysis of the patients with community-acquired pneumonia (CAP) and health care-associated pneumonia (HCAP) requiring hospitalization. Kara S, Akçay MŞ, Ekici Ünsal Z, Bozkurt Yılmaz HE, Habeşoğlu MA. The burden of community-acquired bacterial pneumonia in the era of antibiotic resistance. Peyrani P, Mandell L, Torres A, Tillotson GS. įilmArray® Lower respiratory tract infection Pneumonia Procalcitonin S. pneumoniae Syndromic testing. High levels of inflammation accompany bacterial detection.

PNplus detects severe pneumonia pathogens at a greater rate than conventional microbiology. Median procalcitonin was 0.49 ng/ml and 0.18 ng/ml among patients with ≥ 10 5 and < 10 5 copies/ml of detected bacteria, respectively (p = 0.004). PSI and procalcitonin were greater among patients with bacterial pathogens than viral pathogens. PNplus detection rate was 72.2% compared to 10% by conventional microbiology (p < 0.001) Streptococcus pneumoniae was the most common pathogen. The primary endpoint was the comparative detection rate of pathogens between conventional microbiology and PNplus Panel secondary endpoints were microbiology and the association with the inflammatory host response.įifty-six patients with community-acquired pneumonia without risk factors for multidrug-resistant (MDR) pathogens and another 34 patients with risk factors for MDR were studied median pneumonia severity index (PSI) was 113 (88-135). In a sub-study of the PROGRESS trial, sputum samples of 90 patients with sepsis and LRTI were retrospectively studied. We aimed to describe it using the BioFire ® FilmArray ® Pneumonia plus (PNplus) Panel. The epidemiology of severe lower respiratory tract infections (LRTI) is constantly changing.

Pnplus mirc download